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How does Adderall work? Pharmacokinetic studies of Adderall XR have been conducted in healthy adult and pediatric (6-12 yrs) subjects, and pediatric patients with ADHD. Both Adderall IR tablets and Adderall XR capsules contain d-amphetamine and l-amphetamine salts in the ratio of 3:1. Following administration of Adderall IR, the peak plasma concentrations occurred in about 3 hours for both d-amphetamine and l-amphetamine. The time to reach maximum plasma concentration (Tmax) for Adderall XR is about 7 hours, which is about 4 hours longer compared to Adderall about 4 hours longer compared to Adderall (immediate-release). This is consistent with the extended-release nature of the product.
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